SUN2 antibody (AA 31-695)

Catalog No. ABIN7601278

The Rabbit Polyclonal anti-SUN2 antibody has been validated for WB, ELISA, IHC, IF and ICC. It is suitable to detect SUN2 in samples from Human.

Quick Overview for SUN2 antibody (AA 31-695) (ABIN7601278)

Target: SUN2 (Sad1 and UNC84 Domain Containing 2 (SUN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-SUN2 Antibody

Binding Specificity: AA 31-695

Purpose: Anti-SUN2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-SUN2 Antibody Picoband® (ABIN7601278). Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SUN2 recombinant protein (Position: Q31-L695).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Haque, F., Mazzeo, D., Patel, J. T., Smallwood, D. T., Ellis, J. A., Shanahan, C. M., Shackleton, S. Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J. Biol. Chem. 285: 3487-3498, 2010. 2. Hodzic, D. M., Yeater, D. B., Bengtsson, L., Otto, H., Stahl, P. D. Sun2 is a novel mammalian inner nuclear membrane protein. J. Biol. Chem. 279: 25805-25812, 2004. 3. Ishikawa, K., Nagase, T., Suyama, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 169-176, 1998.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for SUN2

Target: SUN2 (Sad1 and UNC84 Domain Containing 2 (SUN2))

Alternative Name: SUN2

Background:

Synonyms: Interleukin-32, IL-32, Natural killer cells protein 4, Tumor necrosis factor alpha-inducing factor, IL32, NK4, TAIF

Tissue Specificity: Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells.

Background: SUN1 and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins located in the outer nuclear membrane (ONM). The LINC complex provides a connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity.

Molecular Weight: 80 kDa

Gene ID: 25777

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection