PALB2 antibody (AA 45-1186)

Catalog No. ABIN7601758

The Rabbit Polyclonal anti-PALB2 antibody has been validated for WB, ELISA and FACS. It is suitable to detect PALB2 in samples from Human, Mouse and Rat.

Quick Overview for PALB2 antibody (AA 45-1186) (ABIN7601758)

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PALB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-PALB2 Antibody

Binding Specificity: AA 45-1186

Purpose: Anti-PALB2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-PALB2 Antibody Picoband® (ABIN7601758). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PALB2 recombinant protein (Position: K45-S1186).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Antoniou, A. C., Casadei, S., Heikkinen, T., Barrowdale, D., Pylkas, K., Roberts, J., Lee, A., Subramanian, D., De Leeneer, K., Fostira, F., Tomiak, E., Neuhausen, S. L., and 36 others. Breast-cancer risk in families with mutations in PALB2. New Eng. J. Med. 371: 497-506, 2014. 2. Catucci, I., Peterlongo, P., Ciceri, S., Colombo, M., Pasquini, G., Barile, M., Bonanni, B., Verderio, P., Pizzamiglio, S., Foglia, C., Falanga, A., Marchetti, M., and 12 others. PALB2 sequencing in Italian familial breast cancer cases reveals a high-risk mutation recurrent in the province of Bergamo. Genet. Med. 16: 688-694, 2014. 3. Erkko, H., Xia, B., Nikkila, J., Schleutker, J., Syrjakoski, K., Mannermaa, A., Kallioniemi, A., Pylkas, K., Karppinen, S.-M., Rapakko, K., Miron, A., Sheng, Q., and 15 others. A recurrent mutation in PALB2 in Finnish cancer families. Nature 446: 316-319, 2007.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for PALB2

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Alternative Name: PALB2

Background:

Synonyms: Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1, Serpine1, Pai1, Planh1

Tissue Specificity: Ubiquitous.

Background: Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene. This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.

Molecular Weight: 130 kDa

Gene ID: 79728

Pathways: DNA Damage Repair