CD46 antibody (C-Term) (DyLight 488)

Catalog No. ABIN7602768

This Mouse Monoclonal antibody specifically detects CD46 in FACS. It exhibits reactivity toward Human.

Quick Overview for CD46 antibody (C-Term) (DyLight 488) (ABIN7602768)

Target: CD46

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is conjugated to DyLight 488

Application: Flow Cytometry (FACS)

Clone: 9E9

Product Details anti-CD46 Antibody (DyLight 488)

Binding Specificity: C-Term

Purpose: Anti-Human CD46 DyLight® 488 conjugated Antibody(monoclonal, 9E9)

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Human CD46 DyLight® 488 conjugated Antibody (monoclonal, 9E9) -Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CD46.

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, human
1. "Entrez Gene: CD46 CD46 Molecule, complement regulatory protein". 2. Liszewski MK, Post TW, Atkinson JP (1991). "Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster".Annu. Rev. Immunol. 9 (1): 431-55. 3. Taylor CT, Biljan MM, Kingsland CR, Johnson PM (May 1994). "Inhibition of human spermatozoon-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein)". Hum. Reprod.9 (5): 907-11.

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Target Details for CD46

Target: CD46

Alternative Name: CD46

Background:

Synonyms: AHUS2 antibody, Antigen defined by monoclonal antibody, TRA 2 10 antibody, Antigen identified by monoclonal antibody, TRA 2 10 antibody, CD46 antibody, CD46 antigen antibody, CD46 antigen complement regulatory protein antibody, CD46 Molecule antibody, CD46 Molecule complement regulatory protein antibody, Complement membrane cofactor protein antibody, MCP antibody, MCP_HUMAN antibody, Measles virus receptor antibody, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) antibody, Membrane cofactor protein antibody, MGC26544 antibody,MIC10 antibody, TLX antibody, TRA2.10 antibody, Trophoblast leucocyte common antigen antibody, Trophoblast leukocyte common antigen antibody, Trophoblast lymphocyte cross reactive antigen antibody

Tissue Specificity: Expressed in osteoblasts, but not in osteoclasts.

Background: CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. And the encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Molecular Weight: 39 kDa

Gene ID: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization