Presenilin 1 antibody (Catalytic Subunit)

Catalog No. ABIN7602951

This Rabbit Monoclonal antibody specifically detects Presenilin 1 in WB and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Presenilin 1 antibody (Catalytic Subunit) (ABIN7602951)

Target: Presenilin 1 (PSEN1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Presenilin 1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: AECD-16

Product Details anti-Presenilin 1 Antibody

Binding Specificity: Catalytic Subunit

Purpose: Anti-Presenilin 1 Monoclonal Antibody

Characteristics: Anti-Presenilin 1 Monoclonal Antibody (ABIN7602951). Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Presenilin 1 Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) . Requires the other members of the gamma-secretase complex to have a protease activity.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
FC 1:10

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Concentration: Lot specific

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Target Details for Presenilin 1

Target: Presenilin 1 (PSEN1)

Alternative Name: PSEN1

Background:

Synonyms: Monocyte differentiation antigen CD14 ,Myeloid cell-specific leucine-rich glycoprotein,CD14,Monocyte differentiation antigen CD14, urinary form,Monocyte differentiation antigen CD14, membrane-bound form,CD14,

Tissue Specificity: Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes, also expressed by most tissue macrophages. .

Molecular Weight: 25 kDa

UniProt: P49768

Pathways: Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport