FOXG1 antibody (N-Term)

Catalog No. ABIN7603216

The Rabbit Polyclonal anti-FOXG1 antibody has been validated for WB. It is suitable to detect FOXG1 in samples from Human, Mouse and Rat.

Quick Overview for FOXG1 antibody (N-Term) (ABIN7603216)

Target: FOXG1 (Forkhead Box G1 (FOXG1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXG1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FOXG1 Antibody

Binding Specificity: N-Term

Purpose: Anti-FOXG1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-FOXG1 Antibody Picoband® (ABIN7603216). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human FOXG1, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
1. Ariani, F., Hayek, G., Rondinella, D., Artuso, R., Mencarelli, M. A., Spanhol-Rosseto, A., Pollazzon, M., Buoni, S., Spiga, O., Ricciardi, S., Meloni, I., Longo, I., Mari, F., Broccoli, V., Zappella, M., Renieri, A. FOXG1 is responsible for the congenital variant of Rett syndrome. Am. J. Hum. Genet. 83: 89-93, 2008. 2. Bredenkamp, N., Seoighe, C., Illing, N. Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation. Dev. Genes Evol. 217: 227-233, 2007. 3. Brunetti-Pierri, N., Paciorkowski, A. R., Ciccone, R., Mina, E. D., Bonaglia, M. C., Borgatti, R., Schaaf, C. P., Sutton, V. R., Xia, Z., Jelluma, N., Ruivenkamp, C., Bertrand, M., and 10 others. Duplications of FOXG1 in 14q12 are associated with developmental epilepsy, mental retardation, and severe speech impairment. Europ. J. Hum. Genet. 19: 102-107, 2011.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for FOXG1

Target: FOXG1 (Forkhead Box G1 (FOXG1))

Alternative Name: FOXG1

Background:

Synonyms: Bone morphogenetic protein 15, BMP-15, Growth/differentiation factor 9B, GDF-9B, BMP15, GDF9B

Background: Forkhead box protein G1 is a protein that in humans is encoded by the FOXG1 gene. This locus encodes a member of the fork-head transcription factor family. The encoded protein, which functions as a transcriptional repressor, is highly expressed in neural tissues during brain development. Mutations at this locus have been associated with Rett syndrome and a diverse spectrum of neurodevelopmental disorders defined as part of the FOXG1 syndrome. This gene is disregulated in many types of cancer and is the target of multiple microRNAs that regulate the proliferation of tumor cells.

Molecular Weight: 52 kDa

Gene ID: 2290

UniProt: P55316