MTOR antibody (pSer2448)

Catalog No. ABIN7603291

The Rabbit Monoclonal anti-MTOR antibody has been validated for WB and IHC. It is suitable to detect MTOR in samples from Human, Mouse and Rat.

Quick Overview for MTOR antibody (pSer2448) (ABIN7603291)

Target: MTOR (mTOR) (Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MTOR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: IFF-13

Product Details anti-MTOR Antibody

Binding Specificity: pSer2448

Purpose: Anti-Phospho-mTOR (S2448) Rabbit Monoclonal Antibody

Characteristics: Anti-Phospho-mTOR Rabbit Monoclonal Antibody (ABIN7603291). Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Phospho-mTOR (S2448)

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000
IHC 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Target Details for MTOR

Target: MTOR (mTOR) (Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))

Alternative Name: MTOR

Background:

Synonyms: Serine/threonine-protein kinase mTOR,2.7.11.1,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1,MTOR,FRAP, FRAP1, FRAP2, RAFT1, RAPT1,

Tissue Specificity: Expressed in numerous tissues, with highest levels in testis. .

Molecular Weight: 53 kDa

UniProt: P42345

Pathways: PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, BCR Signaling, Warburg Effect