Lamin A/C antibody

Catalog No. ABIN7605400

The Rabbit Monoclonal anti-Lamin A/C antibody has been validated for WB, IHC, IF, IP, ICC and FACS. It is suitable to detect Lamin A/C in samples from Human.

Quick Overview for Lamin A/C antibody (ABIN7605400)

Target: Lamin A/C (LMNA)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: BEO-12

Product Details anti-Lamin A/C Antibody

Purpose: Anti-Lamin A/C LMNA Rabbit Monoclonal Antibody

Characteristics: Anti-Lamin A/C LMNA Rabbit Monoclonal Antibody (ABIN7605400). Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human.

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Lamin A/C

Isotype: IgG

Application Details

Application Notes: WB 1:3000-1:10000
IHC 1:50-1:200
ICC/IF 1:50-1:200
IP 1:50
FC 1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Concentration: Lot specific

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: LMNA

Background:

Synonyms: Prelamin-A/C,Lamin-A/C,70 kDa lamin,Renal carcinoma antigen NY-REN-32,LMNA,LMN1,

Tissue Specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. .

Molecular Weight: 160-180 kDa

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus