Menin antibody

Catalog No. ABIN7605542

The Rabbit Monoclonal anti-Menin antibody (Clone ACBA-13) (ABIN7605542) specifically detects Menin in WB, IHC, IP, IF and ICC. The antibody is reactive with Human samples.

Quick Overview for Menin antibody (ABIN7605542)

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Menin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: ACBA-13

Product Details anti-Menin Antibody

Purpose: Anti-Menin MEN1 Monoclonal Antibody

Characteristics: Anti-Menin MEN1 Monoclonal Antibody (ABIN7605542). Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human.

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Menin Menin, the protein product of the MEN1 gene, is a component of the mixed-lineage leukemia protein (MLL) -containing histone methyltransferase complex that facilitates methylation of histone H3 Lys4 to promote transcriptional activation. Menin functions to suppress proliferation of pancreatic islet cells, at least in part through MLL-mediated activation of the p18INK4c (p18) and p27CIP/KIP (p27) cyclin-dependent kinase inhibitor genes.

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000
IHC 1:50-200
ICC/IF 1:50-200
IP 1:20

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Concentration: 0.5 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Target Details for Menin

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Alternative Name: MEN1

Background:

Synonyms: Cytochrome b-245 heavy chain,1.-.-.-,CGD91-phox,Cytochrome b (558) subunit beta,Cytochrome b558 subunit beta,Heme-binding membrane glycoprotein gp91phox,NADPH oxidase 2,Neutrophil cytochrome b 91 kDa polypeptide,Superoxide-generating NADPH oxidase heavy chain subunit,gp91-1,gp91-phox,p22 phagocyte B-cytochrome,CYBB,NOX2,

Tissue Specificity: Detected in neutrophils (at protein level). .

Molecular Weight: 47 kDa

UniProt: O00255

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity