TRIB3 antibody

Catalog No. ABIN7606576

The Rabbit Monoclonal anti-TRIB3 antibody has been validated for WB and IP. It is suitable to detect TRIB3 in samples from Human.

Quick Overview for TRIB3 antibody (ABIN7606576)

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TRIB3 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: AEIE-20

Product Details anti-TRIB3 Antibody

Purpose: Anti-TRIB3 Monoclonal Antibody

Characteristics: Anti-TRIB3 Monoclonal Antibody (ABIN7606576). Tested in WB, IP applications. This antibody reacts with Human.

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human TRIB3 Disrupts insulin signaling by binding ly to Akt kinases and blocking their activation. May bind ly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity.

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000
IP 1:20

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Concentration: 0.5 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Target Details for TRIB3

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Alternative Name: TRIB3

Background:

Synonyms: RalA-binding protein 1,RalBP1,76 kDa Ral-interacting protein,Dinitrophenyl S-glutathione ATPase,DNP-SG ATPase,Ral-interacting protein 1,RALBP1,RLIP1, RLIP76,

Tissue Specificity: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes. .

Molecular Weight: 40 kDa

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha