IL-8 antibody (AA 31-99)

Catalog No. ABIN728053

This Rabbit Polyclonal antibody specifically detects IL-8 in WB. It exhibits reactivity toward Human. It has been mentioned in 5+ publications

Quick Overview for IL-8 antibody (AA 31-99) (ABIN728053)

Target: IL-8 (IL8) (Interleukin 8 (IL8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL-8 Antibody

Binding Specificity: AA 31-99

Purpose: IL-8/CXCL8 Polyclonal Antibody

Cross-Reactivity: Human

Predicted Reactivity: Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-8

Isotype: IgG

Application Details

Application Notes: WB(1:500-2000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-IL-8 antibody (ABIN728053)

Xu, Huang, Zhang, Li, Zheng, Yu, Chu, Lin, Chen: "Extracts of Bauhinia championii (Benth.) Benth. attenuate the inflammatory response in a rat model of collagen-induced arthritis." in: Molecular medicine reports, Vol. 13, Issue 5, pp. 4167-74, (2017) (PubMed).

Zhang, Tseng, Zhang, Sirin, Corn, Li-Ning-Tapia, Troncoso, Davis, Pettaway, Ward, Frazier, Logothetis, Kolonin: "CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment." in: Nature communications, Vol. 7, pp. 11674, (2016) (PubMed).

Huang, Duan, Qian, Fan, Lv, Zhang, Han, Wu, Guo, Hu, Du, Chen, Jin: "IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma." in: Scientific reports, Vol. 6, pp. 36551, (2016) (PubMed).

Lu, Wei, Shao, Tang, Huang, Zhang, Yang, Jing: "Assessment of atherosclerotic plaques in the rabbit abdominal aorta with interleukin-8 monoclonal antibody-targeted ultrasound microbubbles." in: Molecular biology reports, Vol. 40, Issue 4, pp. 3083-92, (2013) (PubMed).

Ma, Niu, Sun, Wang, Luo, Zhang, Wang: "Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta." in: Archives of toxicology, Vol. 86, Issue 6, pp. 849-56, (2012) (PubMed).

Target Details for IL-8

Target: IL-8 (IL8) (Interleukin 8 (IL8))

Alternative Name: IL-8

Background:

Synonyms: Interleukin-8, Interleukin 8, Interleukin8, (Ala-IL-8)77, (Ser-IL-8)72, 3 10C, 310C, AMCF 1, AMCF1, b ENAP, Bbeta thromboglobulin like protein, beta thromboglobulin like protein, C-X-C motif chemokine 8, CXC chemokine ligand 8, CXCL 8, CXCL8, Emoctakin, GCP 1, GCP-1, GCP/IL-8 protein I, GCP/IL-8 protein II, GCP/IL-8 protein III, GCP/IL-8 protein IV, GCP/IL-8 protein V, GCP/IL-8 protein VI, GCP1, Granulocyte chemotactic protein 1, IL 8, IL-8, IL-8(1-77), IL-8(9-77), IL8, IL8/NAP1 form I, IL8/NAP1 form II, IL8/NAP1 form III, IL8/NAP1 form IV, IL8/NAP1 form V, IL8/NAP1 form VI, IL8_HUMAN, Inteleukin 8, Interleukin8, K 60, K60, LECT, LUCT,

Background: The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

Gene ID: 3576

UniProt: P10145

Pathways: TLR Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Hepatitis C, Autophagy