NKX3-1 antibody (AA 92-224) (CF®568)

Catalog No. ABIN7658013

This anti-NKX3-1 antibody is a Mouse Monoclonal antibody detecting NKX3-1 in IHC and IHC (fp). Suitable for Human.

Quick Overview for NKX3-1 antibody (AA 92-224) (CF®568) (ABIN7658013)

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NKX3-1 antibody is conjugated to CF®568

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: NKX3-1-2576

Product Details anti-NKX3-1 Antibody (CF®568)

Binding Specificity: AA 92-224

Purpose: NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)(NKX3.1/2576), CF568 conjugate

Characteristics: NKX3. 1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21. 2, which frequently undergoes a loss of heterozygosity. NKX3. 1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3. 1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3. 1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (around aa 92-224) of human NKX3.1 protein

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Highly expressed in the prostate and at a lower level in the testis.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for NKX3-1

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Alternative Name: NKX3.1

Background:

Synonyms: NK3 Homeobox 1, Homeobox Protein NK-3 Homolog A, NKX3-1, NKX3A, NK3 Transcription Factor Related, Locus 1 (Drosophila), NK3 Transcription Factor Related, Locus 1, NK Homeobox (Drosophila), Family 3, A, NK3 Transcription Factor Homolog A, NK Homeobox, Family 3, A, Homeobox Protein Nkx-3.1, BAPX2, NKX3

Gene Symbol: NKX3-1

Molecular Weight: 35 kDa

Gene ID: 4824

UniProt: Q99801

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus