PMEPA1 antibody (CF®640R)

Catalog No. ABIN7659302

The Mouse Monoclonal anti-PMEPA1 antibody has been validated for IHC and IHC (fp). It is suitable to detect PMEPA1 in samples from Human.

Quick Overview for PMEPA1 antibody (CF®640R) (ABIN7659302)

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PMEPA1 antibody is conjugated to CF®640R

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: PMEPA1-2697

Product Details anti-PMEPA1 Antibody (CF®640R)

Purpose: PMEPA1 / TMEPAI (Tumor Suppressor Oncoprotein)(PMEPA1/2697), CF640R conjugate

Characteristics: PMEPA1 (prostate transmembrane protein, androgen induced 1 is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1 interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of PMEPA1 is observed in prostate tumors, suggesting that PMEPA1 may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant full-length human PMEPA1 protein

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: SKBR-3 cells. Prostate, Breast or Renal Cell Carcinoma.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for PMEPA1

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Alternative Name: PMEPA1

Background:

Synonyms: PMEPA, PMEPA1, Prostate transmembrane protein, androgen induced 1, Solid tumor-associated 1 protein, STAG1, TMEPAI, Transmembrane prostate androgen-induced protein, Transmembrane, prostate androgen induced RNA

Gene Symbol: PMEPA1

Tissue Expression: Kidney|Ovary|Prostate

Molecular Weight: 32 kDa

Gene ID: 56937

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway