ROR2 antibody (CF®568)

Catalog No. ABIN7659438

This anti-ROR2 antibody is a Mouse Monoclonal antibody detecting ROR2 in IHC and IHC (fp). Suitable for Human.

Quick Overview for ROR2 antibody (CF®568) (ABIN7659438)

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ROR2 antibody is conjugated to CF®568

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: ROR2-1912

Product Details anti-ROR2 Antibody (CF®568)

Purpose: ROR2(ROR2/1912), CF568 conjugate

Characteristics: ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canoncial Wnt-1 and Wnt-3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactyly type B1, or the autosomal recessive skeletal disorder, Robinow syndrome. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Human cultured keratinocytes

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Human breast, pancreas, kidney or GIST.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for ROR2

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Alternative Name: ROR2

Background:

Synonyms: BR, CD49 antigen-like family member B, ROR2, Collagen receptor, DX5, Glycoprotein Ia deficiency included (GPIa), Human platelet alloantigen system 5 (HPA5 included), Integrin alpha II (ITGA2), Platelet alloantigen Br(a), included, Platelet glycoprotein Ia/IIa, Platelet membrane glycoprotein Ia, VLA2,

Gene Symbol: ROR2

Molecular Weight: 120 kDa

Gene ID: 4920

UniProt: Q01974

Pathways: RTK Signaling, WNT Signaling