Tyrosinase-Related Protein 1 antibody (AA 257-377) (CF®405S)

Catalog No. ABIN7661490

This anti-Tyrosinase-Related Protein 1 antibody is a Mouse Monoclonal antibody detecting Tyrosinase-Related Protein 1 in IHC and IHC (fp). Suitable for Human.

Quick Overview for Tyrosinase-Related Protein 1 antibody (AA 257-377) (CF®405S) (ABIN7661490)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Tyrosinase-Related Protein 1 antibody is conjugated to CF®405S

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: TYRP1-3284

Product Details anti-Tyrosinase-Related Protein 1 Antibody (CF®405S)

Binding Specificity: AA 257-377

Purpose: Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)(TYRP1/3284), CF405S conjugate

Characteristics: Reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: A recombinant fragment (around aa 257-377) of human TYRP1 protein

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells. Human Skin or Melanoma.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Alternative Name: Tyrosinase Related Protein-1

Background:

Synonyms: 5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75

Gene Symbol: TYRP1

Tissue Expression: Melanocytes

Molecular Weight: 75 kDa

Gene ID: 7306

UniProt: P17643