CD19 antibody

Catalog No. ABIN7669991

The Rabbit Monoclonal anti-CD19 antibody (Clone HD37) (ABIN7669991) specifically detects CD19 in FACS. The antibody is reactive with Human samples.

Quick Overview for CD19 antibody (ABIN7669991)

Target: CD19 (CD19 Molecule (CD19))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD19 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: HD37

Product Details anti-CD19 Antibody

Purpose: Purified Anti-Human CD19 Antibody[HD37]

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze / thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for CD19

Target: CD19 (CD19 Molecule (CD19))

Alternative Name: CD19

Background: CVID,B-lymphocyteantigenCD,B-lymphocyte antigen CD,T-cellsurfaceantigenLeu,Differentiation antigen CD,T-cell surface antigen Leu,B-lymphocytesurfaceantigenB,B-lymphocyte surface antigen B,B4,CVID3,CD19,B-lymphocyteantigenCD19,B-lymphocytesurfaceantigenB4,T-cellsurfaceantigenLeu-12,B-lymphocyte antigen CD19,B-lymphocyte surface antigen B4,Differentiation antigen CD19,T-cell surface antigen Leu-12,B4,CVID3,CD19,CD19 Molecule,CD19 protein is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses . CD19 is expressed throughout B cell development from pre-B cells through mature B cells, and it is commonly used as a B cell lineage marker . It is required for the responsiveness of mature B cell to antigen stimulation, germinal center development, and antibody affinity maturation . The CD19 protein associates with the B cell antigen receptor (BCR), CD81, CD38, CD21, CD22, and IFITM1/CD225/Leu13. These associations enable CD19 to amplify B cell signaling and reduce the threshold for antigen stimulation through the BCR.

UniProt: P15391

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway