Endoglin antibody

Catalog No. ABIN7670591

This Rabbit Polyclonal antibody specifically detects Endoglin in ELISA. It exhibits reactivity toward Mouse.

Quick Overview for Endoglin antibody (ABIN7670591)

Target: Endoglin (ENG)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endoglin antibody is un-conjugated

Application: ELISA

Product Details anti-Endoglin Antibody

Purpose: Endoglin/CD105 Polyclonal Antibody(Capture/Detector)

Purification: Antigen Affinity Purification

Immunogen: Recombinant Mouse Endoglin/CD105 protein expressed by Mammalian

Isotype: IgG

Application Details

Application Notes: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: Endoglin/CD105

Background: CD105,EndogLin,ENDOsLer-Rendu-Weber syndrome 1,ENG,HHT1FLJ41744,ORW,ORW1,Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin and betaglycan/T beta RIII are type III receptors for TGF beta superfamily ligands,sharing 71 % aa identity in the transmembrane (TM) and cytoplasmic domains. Endoglin is highly expressed on proliferating vascular endothelial cells,chondrocytes,and syncytiotrophoblasts of term placenta,with lower amounts on hematopoietic,mesenchymal and neural crest stem cells,activated monocytes,and lymphoid and myeloid leukemic cells. Human endoglin cDNA encodes 658 amino acids (aa) including a 25 aa signal sequence,a 561 aa extracellular domain (ECD) with an orphan domain and a two-part ZP domain,a TM domain and a 47 aa cytoplasmic domain. An isoform with a 14 aa cytoplasmic domain (S-endoglin) can oppose effects of long (l) endoglin. The human endoglin ECD shares 65-72 % aa identity with mouse,rat,bovine,porcine and canine endoglin. Endoglin homodimers interact with TGF-beta 1 and TGF-beta 3 (but not TGF-beta 2),but only after binding T beta RII. Similarly,they interact with Activin A and BMP-7 via activin type IIA or B receptors,and with BMP-2 via BMPR-IA/AlK-3 or BMPR-IB/AlK-6. BMP-9,however,is reported to bind endoglin directly. Endoglin modifies ligand-induced signaling in multiple ways. For example,expression of endoglin can inhibit TGF-beta 1 signals but enhance BMP?7 signals in the same myoblast cell line

UniProt: Q63961