SAA1 antibody

Catalog No. ABIN7670746

This anti-SAA1 antibody is a Rat Monoclonal antibody detecting SAA1 in ELISA (Capture). Suitable for Human.

Quick Overview for SAA1 antibody (ABIN7670746)

Target: SAA1 (Serum Amyloid A1 (SAA1))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This SAA1 antibody is un-conjugated

Application: ELISA (Capture)

Clone: 40H6

Product Details anti-SAA1 Antibody

Purpose: Serum Amyloid A1/SAA Monoclonal Antibody(Capture)

Purification: Protein A/G Purification

Immunogen: Recombinant Human Serum Amyloid A1/SAA protein expressed by E.coli

Isotype: IgG2a

Application Details

Application Notes: ELISA Capture 2-8 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for SAA1

Target: SAA1 (Serum Amyloid A1 (SAA1))

Alternative Name: Serum Amyloid A1/SAA

Background: Serum amyLoid A-1 protein,SAA,SAA1,The apolipoproteins are a structurally-unrelated group of proteins that have some association with the transport of lipids in blood. Apolipoproteins,plus phospholipids,cholesterol and triglycerides,form spherical particles with a lipid/hydrophobic center and a (apolipo)protein coat. The apolipoprotein coat promotes aqueous solubility and serves as a ligand for lipoprotein receptors. HDl may contain apolipoproteins A,C,D,E,J,l and M,while lDl contains apolipoproteins B and E. ApoAI and ApoA2 are major protein components of serum high-density lipoprotein (HDl) and are produced by the liver and small intestine. They are involved in reverse cholesterol transport from tissues to the liver. Polymorphisms of ApoA2 are associated with disorders of cholesterol and fatty acid metabolism. Human ApoB (Apolipoprotein B-100) is a 550 kDa,secreted,palmitoylated glycoprotein that is part of lDl and VlDl particles. It is made by liver and is 4536 aa in length. It binds lDl to the ApoB/E receptor. ApoC activates lipoprotein lipase and may self-associate to form amyloid-type fibrils. ApoE is a 34 kDa protein component of serum chylomicrons,VlDl,and HDl particles. It mediates the binding,uptake,and catabolism of these particles through interactions with the ApoE receptor and lDl receptors in the liver and brain. ApoE is important in fatty acid homeostasis and memory formation. Polymorphisms encode three variants (ApoE2,3,4) which are differentially related to the development of atherosclerosis and neurogenerative disorders,particularly Alzheimer's disease. Serum amyloid A proteins (SAAs) are a family of homologous apolipoproteins of high density lipoprotein (HDl). They can be divided into two groups. The first group consists of the acute phase SAA1 and SAA2 that associate with HDl during inflammation and remodel the HDl particle by displacing apolipoprotein A1. The second group consists of constitutively expressed SAA4 and SAA5 that exist as minor apolipoproteins on HDl but make up more than 90 % of the total SAA during homeostasis.

UniProt: P0DJI8

Pathways: Toll-Like Receptors Cascades