Mesothelin antibody

Catalog No. ABIN7673469

The Rabbit Polyclonal anti-Mesothelin antibody is suitable to detect Mesothelin in samples from Human. It has been validated for WB, ELISA and IHC.

Quick Overview for Mesothelin antibody (ABIN7673469)

Target: Mesothelin (MSLN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mesothelin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Mesothelin Antibody

Purpose: MSLN antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Mesothelin

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for Mesothelin

Target: Mesothelin (MSLN)

Alternative Name: MSLN

Background:

Synonyms: Mesothelin|CAK1 antigen|Pre-pro-megakaryocyte-potentiating factor|Megakaryocyte-potentiating factor (MPF)|Mesothelin, cleaved form|MSLN|MPF

Background: Mesothelin (MSLN) is a 40 kDa GPI-anchored surface glycoprotein that is expressed on pleural and peritoneal mesothelial cells, but not in other non-neoplastic tissues. The mesothelin gene encodes a 69-71 kDa precursor protein that is processed to a 40 kDa membrane-bound protein termed mesothelin and a 31 kDa shed fragment called megakaryocyte-potentiating factor (MPF) that is released from the cell.

Molecular Weight: 70 kDa, 40 kDa

Gene ID: 10232

UniProt: Q13421

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process