CD22 antibody (PerCP-Cy5.5)

Catalog No. ABIN7674313

This anti-CD22 antibody is a Mouse Monoclonal antibody detecting CD22 in FACS. Suitable for Mouse.

Quick Overview for CD22 antibody (PerCP-Cy5.5) (ABIN7674313)

Target: CD22 (CD22 Molecule (CD22))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD22 antibody is conjugated to PerCP-Cy5.5

Application: Flow Cytometry (FACS)

Clone: Cy34-1

Product Details anti-CD22 Antibody (PerCP-Cy5.5)

Purpose: PerCP-Cy5.5 Anti-Mouse CD22 Antibody

Purification: 0

Purity: 0

Isotype: IgG1, kappa

Application Details

Application Notes: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 % BSA, pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: 4 °C

Storage Comment: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for CD22

Target: CD22 (CD22 Molecule (CD22))

Alternative Name: CD22

Background:

Synonyms: Siglec2|B-cell receptor CD22|B-lymphocyte cell adhesion molecule|BL-CAM|CD22|Cd22|Lyb-8|Sialic acid-binding Ig-like lectin 2|Siglec-2|T-cell surface antigen Leu-14

Background: The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig μ chain are augmented in the presence of Cy34.1 mAb.

Molecular Weight: 0

Gene ID: 12483

UniProt: P35329