MAP3K7 antibody (pThr187)

Catalog No. ABIN7674401

This Rabbit Monoclonal antibody specifically detects MAP3K7 in WB. It exhibits reactivity toward Human.

Quick Overview for MAP3K7 antibody (pThr187) (ABIN7674401)

Target: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MAP3K7 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 0

Product Details anti-MAP3K7 Antibody

Binding Specificity: pThr187

Purpose: Phospho-TAK1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: Peptide

Immunogen: peptide

Isotype: IgG

Application Details

Application Notes: WB: 1:5000-1:20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for MAP3K7

Target: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Alternative Name: TAK1

Background:

Synonyms: MAP3K7|TGF beta activated kinase 1|Mitogen-activated protein kinase kinase kinase 7|mitogen activated protein kinase kinase kinase 7|MAP3K 7

Background: MAP3K7(Mitogen-activated protein kinase kinase kinase 7) is also named TAK1 and belongs to the MAP kinase kinase kinase subfamily. It plays an important role in the cascades of cellular responses evoked by changes in the environment. It has been linked to interleukin-1 receptor and tumor necrosis factor receptor signaling (PMID: 16186825). It has 4 isoforms (53-55 kDa, 64-70 kDa and 75-80 kDa)produced by alternative splicing.

Molecular Weight: 80 kDa

Gene ID: 6885

UniProt: O43318

Pathways: NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway