SPDEF/PSE antibody (AA 251-335) (Biotin)

Catalog No. ABIN735595

This Rabbit Polyclonal antibody specifically detects SPDEF/PSE in IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for SPDEF/PSE antibody (AA 251-335) (Biotin) (ABIN735595)

Target: SPDEF/PSE (SPDEF) (Proximal Sequence Element 1 (SPDEF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPDEF/PSE antibody is conjugated to Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SPDEF/PSE Antibody (Biotin)

Binding Specificity: AA 251-335

Purpose: SPDEF Polyclonal Antibody, Biotin Conjugated

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PDEF

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for SPDEF/PSE

Target: SPDEF/PSE (SPDEF) (Proximal Sequence Element 1 (SPDEF))

Alternative Name: PDEF/SPDEF

Background:

Synonyms: bA375E1.3, PDEF, Prostate derived Ets factor, PROSTATE EPITHELIUM SPECIC ETS TRANSCRIPTION FACTOR, Prostate epithelium-specic Ets transcription factor, Prostate specic Ets, Prostate-derived Ets factor, Prostate-specic Ets, PSE, RP11-375E1__A.3, SAM POINTED DOMAIN CONTAINING ETS TRANSCRIPTION FACTOR, SAM pointed domain-containing Ets transcription factor, Spdef, SPDEF_HUMAN.

Background: SPDEF, also known as PDEF is an ETS transcription factor expressed in the prostate epithelial cells. It is thought to act as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter and also as a transcriptional activator for the SERPINB5 promoter. It is highly expressed in prostate carcinoma cells and is thought to be involved in the regulation of the prostate gland and/or prostate cancer development. It is also expressed in epithelial breast carcinoma.

Gene ID: 25803