Recombinant BRCA1 antibody (AA 525-575)

Catalog No. ABIN7795735

The Rabbit Monoclonal anti-BRCA1 antibody (Clone BLR319M) (ABIN7795735) specifically detects BRCA1 in WB and IP. The antibody is reactive with Mouse samples.

Quick Overview for Recombinant BRCA1 antibody (AA 525-575) (ABIN7795735)

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BRCA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: BLR319M

Product Details anti-BRCA1 Antibody

Binding Specificity: AA 525-575

Purpose: Rabbit anti-BRCA1 Recombinant Monoclonal Antibody [BLR319M]

Purification: Purified

Immunogen: Between 525 and 575

Isotype: IgG

Application Details

Application Notes: IP,6 μL/mg lysate,WB,11000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1000 μg/mL

Buffer: Phosphate Buffered Saline (PBS) with 0.09 % Sodium Azide, BSA-Free

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2 - 8 °C

Expiry Date: 12 months

Target Details for BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Alternative Name: BRCA1

Background: BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.

Gene ID: 12189

UniProt: P48754

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus