MERTK antibody (pTyr749, pTyr753, pTyr754)

Catalog No. ABIN7795874

The Rabbit Polyclonal anti-MERTK antibody has been validated for WB and ELISA. It is suitable to detect MERTK in samples from Human.

Quick Overview for MERTK antibody (pTyr749, pTyr753, pTyr754) (ABIN7795874)

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MERTK antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MERTK Antibody

Binding Specificity: pTyr749, pTyr753, pTyr754

Purpose: Anti-MerTK (Tyr749/753/754) Antibody

Specificity: Specific for the ~160 kDa MerTK protein phosphorylated at Tyr749/753/754. The immunolabeling is completely eliminated by treatment with λ-phosphatase. Due to post-translational modifications of the Mer protein, a significant shift in molecular weight is seen from the predicted molecular weight of 110 kDa. For optimal results immunoprecipitation is recommended due to the 91 % homology of the related receptor tyrosine kinase, Axl, that runs at ~140 kDa.

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Our MerTK Tyr749/753/754 rabbit polyclonal phosphospecific primary antibody is produced in-house. It detects MerTK Tyr749/753/754 and is antigen affinity purified from pooled serum. It is great for use in ELISA, WB.

Purification: Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.

Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr749/753/754 of human MerTK, conjugated to keyhole limpet hemocyanin (KLH).

Isotype: IgG

Application Details

Application Notes: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

Storage Comment: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Expiry Date: 12 months

Target Details for MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Alternative Name: MerTK

Background:

Synonyms: c MER antibody, c mer proto oncogene tyrosine kinase antibody, c-mer antibody, cMER antibody, cmer protooncogene tyrosine kinase antibody, Eyk antibody, MER antibody, MER receptor tyrosine kinase antibody, MERK antibody, MERPEN antibody, Mertk antibody, MERTK c-mer proto-oncogene tyrosine kinase antibody, MERTK_HUMAN antibody, MGC133349 antibody, nmf12 antibody, Nyk antibody, Proto oncogene tyrosine protein kinase MER antibody, Proto oncogene tyrosine protein kinase MER precursor antibody, Proto-oncogene c-Mer antibody, Receptor tyrosine kinase MerTK antibody, RP38 antibody, STK kinase antibody, Tyrosine-protein kinase Mer antibody

Description Logic: Our MerTK Tyr749/753/754 rabbit polyclonal phosphospecific primary antibody is produced . It detects MerTK Tyr749/753/754 and is antigen affinity purified from pooled serum. It is great for use in ELISA, WB.

Gene Name Alternatives: MERTK

Molecular Weight: 160 kDa

Gene ID: 10461

UniProt: Q12866

Pathways: RTK Signaling