SOD1 antibody

Catalog No. ABIN737346

This anti-SOD1 antibody is a Rabbit Polyclonal antibody detecting SOD1 in WB, IHC (p) and IF (p). Suitable for Human, Mouse, Rat and Cow. This Primary Antibody has been cited in 1 publication.

Quick Overview for SOD1 antibody (ABIN737346)

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Reactivity: Human, Mouse, Rat, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-SOD1 Antibody

Cross-Reactivity: Cow, Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse SOD1

Isotype: IgG

Application Details

Application Notes: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

References for anti-SOD1 antibody (ABIN737346)

Li, He, Zhang, Miao: "Differential proteome and gene expression reveal response to carbon ion irradiation in pubertal mice testes." in: Toxicology letters, Vol. 225, Issue 3, pp. 433-44, (2014) (PubMed).

Target Details for SOD1

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Alternative Name: SOD1

Background:

Synonyms: Superoxide Dismutase 1, ALS 1, ALS, ALS1, Amyotrophic lateral sclerosis 1 adult, Amyotrophic lateral sclerosis 1, Cu/Zn SOD, Cu/Zn superoxide dismutase, Homodimer, Indophenoloxidase A, IPOA, Mn superoxide dismutase, SOD 1, SOD, SOD soluble, SOD1, SOD2, SODC, Soluble indophenoloxidase A, Superoxide dismutase 1, Superoxide dismutase 1 soluble, Superoxide dismutase Cu Zn, Superoxide dismutase cystolic, SODC_HUMAN, Superoxide dismutase [Cu-Zn], hSod1, Ipo1, SODC, Ipo-1, Sod-1, CuZnSOD, Cu/Zn-SOD, MGC107553, B430204E11Rik, superoxide-dimutase-1.

Background: SOD1 encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. Mutations in the copper/ zinc superoxide dismutase (SOD1) gene are associated with 15- 20 % of the familial forms of motoneuron disease. This 153 amino acid metalloenzyme is expressed in virtually all cells of all organisms above bacteria and is highly conserved across species, although some minor variations do occur. The incorporation of the mutated form of the SOD1 human gene into a transgenic mouse leads to the onset of the disease that closely resembles the human condition. These animals become weak at about 2-4 months of age and rapidly lose function, which results in death 4- 6 weeks later.

Molecular Weight: 17kDa

Gene ID: 20655

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis