Recombinant ELANE antibody

Catalog No. ABIN7828171

This Rabbit Monoclonal antibody specifically detects ELANE in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant ELANE antibody (ABIN7828171)

Target: ELANE (Elastase, Neutrophil Expressed (ELANE))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ELANE antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A585

Product Details anti-ELANE Antibody

Purpose: Recombinant Neutrophil Elastase Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human Neutrophil Elastase fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000-1:5000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for ELANE

Target: ELANE (Elastase, Neutrophil Expressed (ELANE))

Alternative Name: Neutrophil Elastase

Background: SCN,ELA,Elastase,ELANE,ELA2,GE,HLE,HNE,NE,PMN-E,SCN1,Elastase-2,Medullasin,Neutrophil elastase,Bone marrow serine protease,Human leukocyte elastase,PMN elastase,Elastase 2,Elastase 2 neutrophil,Elastase neutrophil expressed,ELNE,Granulocyte derived elastase,Leukocyte elastase,Neutrophil expressed,PMN E,Polymorphonuclear elastase,Neutrophil Elastase is hematopoietic serine protease that belongs to the chymotrypsin superfamily and plays a critical role in the innate immune function of mature neutrophils and monocytes. Neutrophil elastase is actively synthesized as an inactive zymogen in myelocytic precursor cells of the bone marrow, which then undergoes activation by limited proteolysis and sorting to primary (azurophil) storage granules of mature neutrophil granulocytes for regulated release. Research studies have shown that neutrophils play a significant role in mediating the inflammatory response through the release of neutrophil elastase, which activates pro-inflammatory cytokines and degrades components of the extracellular matrix and Gram-negative bacteria. Mutations in the gene encoding neutrophil elastase, ELA2, have been implicated in hematological diseases such as cyclic and severe congenital neutropenia, which is characterized by defects in promyelocyte maturation. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 29 kDa

Observed MW: 29 kDa

UniProt: P08246