Recombinant MEK1 antibody (pThr292)

Catalog No. ABIN7828396

This Rabbit Monoclonal antibody specifically detects MEK1 in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant MEK1 antibody (pThr292) (ABIN7828396)

Target: MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MEK1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A821

Product Details anti-MEK1 Antibody

Binding Specificity: pThr292

Purpose: Recombinant Phospho-MEK1 (Thr292) Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for MEK1

Target: MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

Alternative Name: MEK1

Background: MEK,MKK,CFC,MAPKK,PRKMK,MAP2K,CFC3,MAPKK1,MEK1,MKK1,PRKMK1,MAP2K1,Dual specificity mitogen activated protein kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 1,ERK activator kinase 1,kinase 1,MAP kinase kinase 1,MAP kinase/Erk kinase 1,MAPK/ERK kinase 1,MAPKK 1,MEK 1,MEKK1,Mitogen activated protein kinase kinase 1,MKK 1,MP2K1,Protein kinase mitogen activated,Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1),MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation. Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx. Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells. MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 43 kDa

Observed MW: 43 kDa

UniProt: Q02750

Pathways: MAPK Signaling, RTK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling