Recombinant ERBB3 antibody

Catalog No. ABIN7828519

This Rabbit Monoclonal antibody specifically detects ERBB3 in WB. It exhibits reactivity toward Human and Rat.

Quick Overview for Recombinant ERBB3 antibody (ABIN7828519)

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ERBB3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A539

Product Details anti-ERBB3 Antibody

Purpose: Recombinant ErbB3/HER3 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human ErbB3 / HER3 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Alternative Name: ErbB3/HER3

Background: HER,LCCS,Proto-oncogene-like protein c-ErbB,Tyrosine kinase-type cell surface receptor HER,MDA-BF,p180-ErbB,p45-sErbB,p85-sErbB,ERBB3,ErbB-3,HER3,LCCS2,MDA-BF-1,c-erbB-3,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3,Proto-oncogene-like protein c-ErbB-3,Tyrosine kinase-type cell surface receptor HER3,EEBB3,HER3/ErbB3 is a member of the ErbB receptor protein tyrosine kinase family, but it lacks tyrosine kinase activity. Tyrosine phosphorylation of ErbB3 depends on its association with other ErbB tyrosine kinases. Upon ligand binding, heterodimers form between ErbB3 and other ErbB proteins, and ErbB3 is phosphorylated on tyrosine residues by the activated ErbB kinase. There are at least 9 potential tyrosine phosphorylation sites in the carboxy-terminal tail of ErbB3. These sites serve as consensus binding sites for signal transducing proteins, including Src family members, Grb2, and the p85 subunit of PI3 kinase, which mediate ErbB downstream signaling. Both Tyr1222 and Tyr1289 of ErbB3 reside within a YXXM motif and participate in signaling to PI3K. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 148 / 77 kDa

Observed MW: 185 / 98 kDa The actual band is not consistent with the expectation.

UniProt: P21860

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway