Recombinant SIGIRR antibody

Catalog No. ABIN7828564

This Rabbit Monoclonal antibody specifically detects SIGIRR in WB. It exhibits reactivity toward Mouse.

Quick Overview for Recombinant SIGIRR antibody (ABIN7828564)

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SIGIRR antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A360

Product Details anti-SIGIRR Antibody

Purpose: Recombinant SIGIRR Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human SIGIRR fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for SIGIRR

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Alternative Name: SIGIRR

Background: Tir,Tir8,Sigirr,Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 46 kDa

Observed MW: 80 kDa The actual band is not consistent with the expectation.

UniProt: Q9JLZ8

Pathways: Toll-Like Receptors Cascades