Recombinant TYMS antibody

Catalog No. ABIN7828623

The Rabbit Monoclonal anti-TYMS antibody (Clone A524) (ABIN7828623) specifically detects TYMS in IF, WB and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant TYMS antibody (ABIN7828623)

Target: TYMS (Thymidylate Synthetase (TYMS))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TYMS antibody is un-conjugated

Application: Immunofluorescence (IF), Western Blotting (WB), Flow Cytometry (FACS)

Clone: A524

Product Details anti-TYMS Antibody

Purpose: Recombinant Thymidylate Synthase Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human Thymidylate Synthase fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:2000,IF 1:50,FCM 1:50-1:100

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Alternative Name: Thymidylate Synthase

Background: HST,OK/SW-cl,TYMS,HST422,TMS,TS,thymidylate synthase,OK/SW-cl.29,HST422,thymidylate synthase,TMS,thymidylate synthetase,Thymidylate synthase is a homodimer composed of two 30 kDa subunits, which catalyze the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), an essential step in the formation of thymine nucleotides. Thymidylate synthase is an intracellular enzyme that provides the sole de novo source of thymidylate, making it a required enzyme in DNA biosynthesis with activity highest in proliferating cells. Being the exclusive source of dTMP, investigators have concluded that TS is also an important target for anticancer agents such as 5-fluorouracil (5-FU). 5-FU acts as a TS inhibitor and is active against solid tumors such as colon, breast, head, and neck. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 36 kDa

Observed MW: 36 kDa

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases