Recombinant TGFB1 antibody

Catalog No. ABIN7828634

The Rabbit Monoclonal anti-TGFB1 antibody is suitable to detect TGFB1 in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for Recombinant TGFB1 antibody (ABIN7828634)

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TGFB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A618

Product Details anti-TGFB1 Antibody

Purpose: Recombinant TGF beta 1 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human TGF beta 1 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000,IHC 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for TGFB1

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Alternative Name: TGF beta 1

Background: DPD,Transforming growth factor beta,TGF-B,TGFB1,CED,DPD1,LAP,TGFB,TGFbeta,TGF-β,Cartilage-inducing factor,Differentiation inhibiting factor,IBDIMDE,TGF-B1,TGF-beta 1,TGF-beta-1,TGF-β1,Transforming growth factor beta-1 proprotein,Latency-associated peptide,Transforming growth factor beta-1,beta 1,Prepro transforming growth factor beta 1,TGF beta,TGF beta 1,TGF beta 1 protein,Tgfb-1,TGF-beta 1 protein,TGFbeta1,TGF-beta1,TGF-beta-5,transforming growth factor,Transforming Growth Factor b1,Transforming Growth Factor beta 1,Transforming growth factor beta 1a,Transforming Growth Factor-1,Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis. TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII), and type III (RIII). Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases. The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain. Expression of the type III receptor can regulate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 44 kDa

Observed MW: 44, 10 kDa The actual band is not consistent with the expectation.

UniProt: P01137

Pathways: EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints