Recombinant IGF1R antibody

Catalog No. ABIN7829646

The Human Chimeric anti-IGF1R antibody (Clone DMC721) (ABIN7829646) specifically detects IGF1R in FACS. The antibody is reactive with Human samples.

Quick Overview for Recombinant IGF1R antibody (ABIN7829646)

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Antibody Type: Recombinant Antibody

Fragment: Fc fragment

Reactivity: Human

Host: Human, Rabbit

Clonality: Chimeric

Conjugate: This IGF1R antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: DMC721

Product Details anti-IGF1R Antibody

Purpose: Anti-IGF-1R antibody(DMC721), IgG1 Chimeric mAb

Purification: Purified from cell culture supernatant by affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Flow Cyt 1/100

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for IGF1R

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Alternative Name: IGF-1R

Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

UniProt: P08069

Pathways: RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy