CYP21A2 antibody (AA 101-200) (Cy3)

Catalog No. ABIN740358

The Cy3-conjugated Rabbit Polyclonal anti-CYP21A2 antibody (ABIN740358) specifically detects CYP21A2 in IF (cc) and IF (p). The antibody is reactive with Rat samples.

Quick Overview for CYP21A2 antibody (AA 101-200) (Cy3) (ABIN740358)

Target: CYP21A2 (Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 (CYP21A2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP21A2 antibody is conjugated to Cy3

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CYP21A2 Antibody (Cy3)

Binding Specificity: AA 101-200

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CYP21

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CYP21A2

Target: CYP21A2 (Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 (CYP21A2))

Alternative Name: Cyp21

Background:

Synonyms: Cytochrome P450 21, cytochrome P450, family 21, subfamily A, polypeptide 2, 21-OH, 21OHA, 21OHB, CA21H, CAH1, CHOLESTEROL 21-HYDROXYLASE, CPS1, CYP21, Cyp21-ps1, Cyp21a1, CYP21A2, Cyp21a2-ps, CYP21B, CYP21OH-A, MGC150536, MGC150537, MGC156449, Oh21-1, Oh21-2, P450C21, P450c21B, CYP21A2, CP21A_HUMAN.

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene, gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Gene ID: 1589

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process