PSME4 antibody (AA 840-1140)

Catalog No. ABIN7833480

This Rabbit Polyclonal antibody specifically detects PSME4 in WB. It exhibits reactivity toward Arabidopsis thaliana.

Quick Overview for PSME4 antibody (AA 840-1140) (ABIN7833480)

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Reactivity: Arabidopsis thaliana

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSME4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PSME4 Antibody

Binding Specificity: AA 840-1140

Purpose: Anti-PA200 | Proteasome activator PA200

Cross-Reactivity (Details): Arabidopsis thaliana
Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Purification: Serum

Immunogen: PA200 antibodies were generated against a partial fragment encompassing residues 840-1140 Arabidopsis thaliana protein sequence UniProt:F4JC97-1

Application Details

Application Notes: 1 : 500 (WB)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: For reconstitution add 50 μL, of sterile water

Buffer: Serum

Handling Advice: Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube

Storage: -20 °C,-80 °C

Storage Comment: Store lyophilized/reconstituted at -20°C (short tem, months) or at -80°C (long term, years) , once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Target Details for PSME4

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Alternative Name: PA200

Background: PA200 (Proteasome activator PA200) is an associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. It also recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved in DNA damage response: binds to acetylated histones and promotes degradation of histones. Protein levels increase upon exposure of seedlings to MG132, a specific, potent, reversible, and cell-permeable proteasome inhibitor. Alternative names: Proteasome activator subunit 4, Proteasome activating protein 200.

Molecular Weight: 202.9 | ca. 200 kDa

Gene ID: 820533

UniProt: F4JC97-1

Pathways: DNA Replication, Synthesis of DNA