ASIC1 antibody (PE)

Catalog No. ABIN742435

This Rabbit Polyclonal antibody specifically detects ASIC1 in WB. It exhibits reactivity toward Mouse, Human, Rat, Cow and Chicken.

Quick Overview for ASIC1 antibody (PE) (ABIN742435)

Target: ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))

Reactivity: Mouse, Human, Rat, Cow, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASIC1 antibody is conjugated to PE

Application: Western Blotting (WB)

Product Details anti-ASIC1 Antibody (PE)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ASIC1

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ASIC1

Target: ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))

Alternative Name: ASIC1/BNaC2/ASIC1A

Background:

Synonyms: Acid-sensing ion channel 1, ASICs1, Acid sensing ion channel 1, Acid sensing ion channel 1a protein, Acid sensing ion channel, AI843610, Amiloride sensitive cation channel 2 neuronal, ASIC, ASIC1, ASIC1A, B530003N02Rik, BNAC2, Brain sodium channel 2, Cation channel amiloride sensitive neuronal 2, hBNaC2.

Background: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

Molecular Weight: 58kDa

Gene ID: 41