Recombinant Ret Proto-Oncogene antibody (C-Term)

Catalog No. ABIN7865342

The Mouse Monoclonal anti-Ret Proto-Oncogene antibody is suitable to detect Ret Proto-Oncogene in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant Ret Proto-Oncogene antibody (C-Term) (ABIN7865342)

Target: Ret Proto-Oncogene (RET)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ret Proto-Oncogene antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: R3F8

Product Details anti-Ret Proto-Oncogene Antibody

Binding Specificity: C-Term

Expression System: CHO Cells

Purpose: Recombinant RET Proto-oncogene (Medullary Thyroid Carcinoma Marker) Antibody

Specificity: The ret-proto-oncogene encodes a cell surface glycoprotein belonging to the tyrosine-kinase receptor family. Three main splice variants have been identified. Immunoreactivity of the ret-proto-oncogene in normal tissue has been found in Schwann cells, sympathetic ganglion, adrenal medulla, astrocytes and cortical neurons.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Prokaryotic recombinant fusion protein corresponding to the extreme C-terminal cytoplasmic region of the human ret oncoprotein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Ret Proto-Oncogene

Target: Ret Proto-Oncogene (RET)

Alternative Name: RET Proto-oncogene

Background:

Cadherin family member 12 (CDHF12), Cadherin related family member 16 (CDHR16), ELKS, HSCR1, Hydroxyaryl protein kinase, MEN2A, MEN2B, MTC1, Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Oncogene RET, Proto-oncogene c-Ret, Proto-oncogene tyrosine-protein kinase receptor ret, PTC, RET, RET ELE1, RET51, RET9

Human brain, breast, colon or prostate carcinoma.

Molecular Weight: 150kDa (precursor), 170kDa (Mature)

Gene ID: 5979, 350321

UniProt: P07949

Pathways: RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation