Recombinant Cathepsin D antibody

Catalog No. ABIN7857753

The Rabbit Monoclonal anti-Cathepsin D antibody is suitable to detect Cathepsin D in samples from Human. It has been validated for WB and IHC.

Quick Overview for Recombinant Cathepsin D antibody (ABIN7857753)

Target: Cathepsin D (CTSD)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Cathepsin D antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: CTSD-9613R

Product Details anti-Cathepsin D Antibody

Expression System: CHO Cells

Purpose: Recombinant Cathepsin D (Tumor Marker) Antibody

Specificity: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52 kDa preprocathepsin D that is cleaved and glycosylated to form a 48 kDa procathepsin D and then further cleaved to produce 34 kDa and 14 kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: His-tagged CTSD protein

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Cathepsin D

Target: Cathepsin D (CTSD)

Alternative Name: Cathepsin D

Background:

CatD, Cathepsin D, Ceroid lipofuscinosis neuronal 10, CLN10, CPSD, Epididymis secretory sperm binding protein Li 130P, Lysosomal aspartyl peptidase, Lysosomal aspartyl protease

Human kidney, liver, lung or breast tissues. Brain, Heart, Skeletal muscle, Skin or Pancreas

Molecular Weight: 48kDa (Procathepsin D), 34kDa (Cathepsin D), 14kDa (Cathepsin D)

Gene ID: 1509, 654447

UniProt: P07339

Pathways: Peptide Hormone Metabolism