Recombinant CRYAB antibody

Catalog No. ABIN7865474

The Mouse Monoclonal anti-CRYAB antibody is suitable to detect CRYAB in samples from Human. It has been validated for WB and IHC.

Quick Overview for Recombinant CRYAB antibody (ABIN7865474)

Target: CRYAB (Crystallin, alpha B (CRYAB))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CRYAB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: RG2JF

Product Details anti-CRYAB Antibody

Expression System: CHO Cells

Purpose: Recombinant Crystallin Alpha B / CRYAB (Marker of Metaplastic Carcinoma) Antibody

Specificity: Alpha B crystallin is a lens protein which has some homology with the small heat shock proteins. It is expressed in tissues such as skeletal muscle, cardiac muscle, smooth muscle, renal tubular epithelium, Schwann cells, glial cells, thyroid epithelium, colonic epithelium and stratified squamous epithelium. Alpha B crystallin is also reported to be found in ubiquitinated intermediate filament inclusion bodies, such as Lewy bodies (neurofilaments), Rosenthal fibres (glial filaments) and Mallory bodies (cytokeratins). Alpha B crystallin is rarely found in neurofibrillary tangles. The role of Alpha B crystallin in these inclusion bodies is unknown, however, it may function as an accessory protein for intermediate filament aggregation.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Synthetic peptide hemocyanin conjugate. The peptide corresponds to human alpha B crystallin amino acids 1 to 10.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for CRYAB

Target: CRYAB (Crystallin, alpha B (CRYAB))

Alternative Name: Crystallin Alpha B

Background:

AACRYA, Alpha B crystallin, Alpha-crystallin B chain, CRYA2, CTTP2, Heat shock 20 kD like protein, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY REN 27, Rosenthal fiber component

Human heart, kidney or brain.

Molecular Weight: Predicted: 20kDa, Observed: 22-30kDa

Gene ID: 1410, 53454

UniProt: P02511