Recombinant TGFBR1 antibody

Catalog No. ABIN7865491

This Mouse Monoclonal antibody specifically detects TGFBR1 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant TGFBR1 antibody (ABIN7865491)

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TGFBR1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: RG3E6

Product Details anti-TGFBR1 Antibody

Expression System: CHO Cells

Purpose: Recombinant Transforming Growth Factor Beta Receptor 1 (TGFBR1) Antibody

Specificity: Transforming growth factor beta (TGFB) inhibits cell proliferation and stimulates cell differentiation. This is achieved through a receptor complex of types I and II TGFB receptors. The type II receptor is a transmembrane serine/threonine kinase which is able to bind TGFB and transactivate the type I receptor. TGFB receptors are found in all myometrial tissues and, in the kidney, they are found exclusively in renal tubular cells. In normal gastric mucosa, type I and II receptors are demonstrated in fundic glands, but not on surface mucous cells and in normal small bowel and colon, TGFB receptors are expressed in the epithelial cells of the upper crypts.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Prokaryotic recombinant protein corresponding to the external domain of the human transforming growth factor beta receptor type 1 molecule

Isotype: IgM, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for TGFBR1

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Alternative Name: Transforming Growth Factor Beta Receptor 1

Background:

ALK5 | SKR4

Human placenta, spleen or liver. HEK293T cells.

Molecular Weight: 53kDa

Gene ID: 7046

UniProt: P36897

Pathways: Growth Factor Binding