Recombinant INSM1 antibody (N-Term)

Catalog No. ABIN7857867

The Rabbit Monoclonal anti-INSM1 antibody is suitable to detect INSM1 in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant INSM1 antibody (N-Term) (ABIN7857867)

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This INSM1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: INSM1-6286R

Product Details anti-INSM1 Antibody

Binding Specificity: AA 81-125, N-Term

Expression System: HEK-293 Cells

Purpose: Recombinant INSM1 (Pan-Neuroendocrine Marker) Antibody

Specificity: Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95 % of lung small cell carcinoma and 91 % of lung large cell neuroendocrine carcinoma, compared with 75 % and 78 % with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56).INSM1 stains 100 % of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3 % of adenocarcinomas and 4 % of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.

Purification: 200ug/ml of Ab produced in HEK293 cell mammalian-based expression system.

Immunogen: Recombinant fragment (around aa81-125) corresponding to the N-terminus of human INSM1

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for INSM1

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Alternative Name: INSM1

Background:

IA1, Insulinoma associated protein 1 (IA1), Zinc finger protein IA1

Human pancreas or neuroendocrine tumor.

Molecular Weight: 58kDa

Gene ID: 3642, 89584

UniProt: Q01101