Recombinant INSM1 antibody (AA 1-300)

Catalog No. ABIN7858830

The Rabbit Monoclonal anti-INSM1 antibody is suitable to detect INSM1 in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant INSM1 antibody (AA 1-300) (ABIN7858830)

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This INSM1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: INSM1-8122R

Product Details anti-INSM1 Antibody

Binding Specificity: AA 1-300

Purpose: Recombinant INSM1 (Pan-Neuroendocrine Marker) Antibody

Specificity: Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation.INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95 % of lung small cell carcinoma and 91 % of lung large cell neuroendocrine carcinoma, compared with 75 % and 78 % with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56).INSM1 stains 100 % of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3 % of adenocarcinomas and 4 % of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-300) of human INSM1 (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for INSM1

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Alternative Name: INSM1

Background:

IA1, Insulinoma associated protein 1 (IA1), Zinc finger protein IA1

Human pancreas or neuroendocrine tumor.

Molecular Weight: 58kDa

Gene ID: 3642, 89584

UniProt: Q01101