Recombinant TNFSF15 antibody

Catalog No. ABIN7857979

The Rabbit Monoclonal anti-TNFSF15 antibody (Clone VEGI-7799R) (ABIN7857979) specifically detects TNFSF15 in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant TNFSF15 antibody (ABIN7857979)

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TNFSF15 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: VEGI-7799R

Product Details anti-TNFSF15 Antibody

Purpose: Recombinant TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Antibody

Specificity: VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.

Purification: 200ug/ml of Ab purified by Protein A Column.

Immunogen: Recombinant full-length human VEGI protein

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for TNFSF15

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Alternative Name: TNFS15

Background:

TNF ligand-related molecule 1 (TL1A), Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15), Vascular endothelial growth inhibitor 192a, Vascular endothelial growth inhibitor (VEGI), VEGI192A

Endothelial cells. Colon|intestine|lung or prostate.|Placenta

Molecular Weight: 22kDa

Gene ID: 9966, 241382

UniProt: O95150

Pathways: Positive Regulation of Endopeptidase Activity, Autophagy