Recombinant PD-1 antibody (Extracellular Domain)

Catalog No. ABIN7864047

This Rabbit Monoclonal antibody specifically detects PD-1 in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Recombinant PD-1 antibody (Extracellular Domain) (ABIN7864047)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PD-1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: PDCD1-7276R

Product Details anti-PD-1 Antibody

Binding Specificity: Extracellular Domain

Purpose: Recombinant PDCD1 / PD1 / CD279 (Programmed Cell Death 1) Antibody

Specificity: PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.

Purification: 200ug/ml of Ab purified by Protein A/G.

Immunogen: Recombinant fragment corresponding to extracellular domain of human PDCD1 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name: PDCD1

Background:

CD279, hPD-1, hSLE1, PD1, PDCD1, Programmed Cell Death Protein 1, Protein PD-1, SLEB2, Systemic lupus erythematosus susceptibility 2

Human tonsil|lymph node or appendix.

Molecular Weight: 55kDa

Gene ID: 5133, 158297

UniProt: Q15116

Pathways: Cancer Immune Checkpoints