CCL23 antibody (AA 1-120)

Catalog No. ABIN7864500

This Mouse Monoclonal antibody specifically detects CCL23 in IHC. It exhibits reactivity toward Human.

Quick Overview for CCL23 antibody (AA 1-120) (ABIN7864500)

Target: CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCL23 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: CCL23-4034

Product Details anti-CCL23 Antibody

Binding Specificity: AA 1-120

Purpose: CCL23 / Myeloid Progenitor Inhibitory Factor 1 Antibody

Specificity: Small inducible cytokine A23 precursor (CCL23), or CK-b-8, is a chemokine that binds to the receptor CCR1. It is involved in the immune response and inhibits production of polymorphonuclear leukocytes (PMNs) and monocytes in bone marrow. In addition, CCL23 has a splice variant, CK-b-8-1, and both variants chemoattract lymphocytes, monoctyes and neutrophils. CCL23 also promotes angiogenesis and endothelial cell migration via its actions on the CCR1 receptor. Proinflammatory proteases cleave an N-terminal domain of CCL23, improving the potency of its CCR1-mediated signaling up to 1000- fold in vitro. N-truncated CCL23 is found in high levels in synovial fluids of rheumatoid arthritis patients, suggesting a role of protease release during an inflammatory response. High levels of CCL23 mRNA expression occur in human fetal bone osteoblasts and chondrocytes, indicating a possible role for CCL23 in the recruitment of osteoclast precursors to the sites of bone reabsorption.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-120) of human CCL23 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for CCL23

Target: CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))

Alternative Name: CCL23

Background:

C C motif chemokine ligand 23, C6 beta chemokine, CK-beta-8, CKB 8, Ckb-8-1, CKB8, Hmrp-2a, Macrophage inflammatory protein 3, MIP3, MPIF1, Myeloid progenitor inhibitory factor 1, OTTHUMP00000163948, SCYA 23, SCYA23, Small inducible cytokine subfamily A (Cys-Cys), member 23, Small inducible cytokine subfamily A, member 23

High levels in adult lung|liver|skeletal muscle and pancreas.

Molecular Weight: 13kDa

Gene ID: 6368, 169191

UniProt: P55773