Recombinant CD7 antibody (AA 1-200)

Catalog No. ABIN7864327

This Rabbit Monoclonal antibody specifically detects CD7 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant CD7 antibody (AA 1-200) (ABIN7864327)

Target: CD7

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD7 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: CD7-8357R

Product Details anti-CD7 Antibody

Binding Specificity: AA 1-200

Purpose: Recombinant CD7 (T-Cell Leukemia Marker) Antibody

Specificity: Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 1-200) of human CD7 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for CD7

Target: CD7

Alternative Name: CD7

Background:

GP40, Leu9, p41, T-cell leukemia antigen, T-cell surface antigen Leu-9, Tp40, TP41

HePG-2 or Jurkat cells. Human lymph node or tonsil.

Molecular Weight: 40kDa

Gene ID: 924, 186820

UniProt: P09564

Pathways: Cell-Cell Junction Organization