FAP antibody (AA 1-200)

Catalog No. ABIN7862798

This Mouse Monoclonal antibody specifically detects FAP in IHC. It exhibits reactivity toward Human.

Quick Overview for FAP antibody (AA 1-200) (ABIN7862798)

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FAP antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: FAP-4854

Product Details anti-FAP Antibody

Binding Specificity: AA 1-200

Purpose: Fibroblast Activation Protein Alpha / FAP-1 Antibody

Specificity: FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 1-200) of human FAP protein (exact sequence is proprietary)

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for FAP

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Alternative Name: Fibroblast Activation Protein Alpha

Background:

170 kDa melanoma membrane-bound gelatinase, DPPIV, FAP, FAPA, Fibroblast activation protein alpha, Integral membrane serine protease, Seprase

Human uterus, colon or pancreas. Fibroblast specific.

Molecular Weight: 88kDa

Gene ID: 2191, 654370

UniProt: Q12884

Pathways: Tube Formation