Kallikrein 7 antibody (AA 1-200)

Catalog No. ABIN7858586

This Mouse Monoclonal antibody specifically detects Kallikrein 7 in IHC. It exhibits reactivity toward Human.

Quick Overview for Kallikrein 7 antibody (AA 1-200) (ABIN7858586)

Target: Kallikrein 7 (KLK7)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Kallikrein 7 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: KLK7-4693

Product Details anti-Kallikrein 7 Antibody

Binding Specificity: AA 1-200

Purpose: KLK7 (Kallikrein Related Peptidase 7) Antibody

Specificity: Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13.41. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein or HGK-1, and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. KLK4, KLK5, KLK9, KLK13, KLK12 and KLK14 have been previously known as KLK-L1, KLK-L2, KLK-L3, KLK-L4, KLK-L5 and KLK-L6, respectively. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human KLK7 protein (around aa 1-200) (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Kallikrein 7

Target: Kallikrein 7 (KLK7)

Alternative Name: KLK7

Background:

Chymotryptic stratum corneum, hK7, hSCCE, Kallikrein 7 (chymotryptic stratum corneum), Kallikrein related peptidase 7, Protease serine 6, PRSS6, SCCE, Serine protease 6, Signal protein, Stratum corneum chymotryptic enzyme

Human skin tissue (IHC).

Molecular Weight: 27kDa

Gene ID: 5650, 151254

UniProt: P49862

Pathways: Complement System