Recombinant Keratin 6 antibody (AA 1-200)

Catalog No. ABIN7858596

The Rabbit Monoclonal anti-Keratin 6 antibody is suitable to detect Keratin 6 in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant Keratin 6 antibody (AA 1-200) (ABIN7858596)

Target: Keratin 6 (KRT6)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Keratin 6 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: KRT6-8198R

Product Details anti-Keratin 6 Antibody

Binding Specificity: AA 1-200

Purpose: Recombinant Cytokeratin 6 / KRT6 (Pan, a,b,c) (Basal Cell Marker) Antibody

Specificity: Cytokeratin 6 is an epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. This protein always paired with the type-I keratin K16.Cytokeratin 6 have been identified in epidermis only in samples from plantar glabrous skin while in hairy skin this keratin appeared to be absent in interfollicular epidermis but were clearly present in hair follicle outer root sheath, and this protein also consistently expressed in non-keratinizing stratified squamous epithelia. Among tumors, cytokeratin 6 is typically and strongly expressed in squamous cell carcinomas of different sites, preferentially in inner, maturing layers of the tumor cell nests. Cytokeratin 6 is always used with cytokeratin 5 and is a useful aid for classification of epithelioid mesotheliomas.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human KRT6 (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Keratin 6

Target: Keratin 6 (KRT6)

Alternative Name: Cytokeratin 6

Background:

CK6A, CK6B, CK6C, CK6D, CK6E, Keratin Type II Cytoskeletal 6A, Keratin Type II Cytoskeletal 6B, Keratin Type II

Human tonsil or basal cell carcinoma (BCC).

Molecular Weight: 56kDa

Gene ID: 3853, 700779

UniProt: P02538