Hexokinase 1 antibody (AA 1-250)

Catalog No. ABIN7865350

The Mouse Monoclonal anti-Hexokinase 1 antibody is suitable to detect Hexokinase 1 in samples from Human. It has been validated for IHC.

Quick Overview for Hexokinase 1 antibody (AA 1-250) (ABIN7865350)

Target: Hexokinase 1 (HK1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Hexokinase 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: HK1-9514

Product Details anti-Hexokinase 1 Antibody

Binding Specificity: AA 1-250

Purpose: HK1 / Hexokinase 1 Antibody

Specificity: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-250) of human HK1 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Hexokinase 1

Target: Hexokinase 1 (HK1)

Alternative Name: HK1

Background:

Neuropathy, hereditary motor and sensory, Russe type

Human brain.

Molecular Weight: 102kDa

Gene ID: 3098, 370365

UniProt: P19367

Pathways: Carbohydrate Homeostasis, Warburg Effect