BCOR antibody (AA 100-400)

Catalog No. ABIN7864482

The Mouse Monoclonal anti-BCOR antibody (Clone BCOR-1311) (ABIN7864482) specifically detects BCOR in IHC. The antibody is reactive with Human samples.

Quick Overview for BCOR antibody (AA 100-400) (ABIN7864482)

Target: BCOR (BCL6 Co-Repressor (BCOR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BCOR antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: BCOR-1311

Product Details anti-BCOR Antibody

Binding Specificity: AA 100-400

Purpose: BCOR Antibody

Specificity: Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFé 79oΩB expression, thereby inhibiting NFé 79oΩB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin s lymphoma. BCoR (Bcl-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its three ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 100-400) of human BCOR protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for BCOR

Target: BCOR (BCL6 Co-Repressor (BCOR))

Alternative Name: BCOR

Background:

ANOP2, BCL 6 interacting corepressor, BCL6 interacting corepressor, BCoR, KIAA1575, MAA2, MCOPS2

Ubiquitously expression.

Molecular Weight: 192kDa

Gene ID: 54880, 659681

UniProt: Q6W2J9