IL1A antibody (AA 113-271)

Catalog No. ABIN7862993

The Mouse Monoclonal anti-IL1A antibody is suitable to detect IL1A in samples from Human. It has been validated for IHC.

Quick Overview for IL1A antibody (AA 113-271) (ABIN7862993)

Target: IL1A (Interleukin 1 alpha (IL1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL1A antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: IL1A-3982

Product Details anti-IL1A Antibody

Binding Specificity: AA 113-271

Purpose: Interleukin-1 alpha (IL-1 alpha) Antibody

Specificity: Two forms of interleukin-1, designated IL-1°™and IL-1 æ, have been described. Although encoded by distinct genes and exhibiting roughly only 25 % sequence identity, IL-1°™ and IL-1 æ bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1 æ for production of the anti-pathogen IFN-Á. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 113-271) of human IL1A protein

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for IL1A

Target: IL1A (Interleukin 1 alpha (IL1A))

Alternative Name: Interleukin-1 alpha

Background:

BAF, FAF, Hematopoietin 1, IL 1 alpha, IL1F1, Interleukin 1 alpha, LAF, LEM, Preinterleukin 1 alpha, Pro interleukin 1 alpha

HeLa cells. Human colon carcinoma tissue.

Molecular Weight: 33kDa (proprotein), 17kDa (mature)

Gene ID: 3552, 1722

UniProt: P01583

Pathways: NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints